The Table of Contents

SECTION ONE

CHAPTER ONE
HORMONE HAVOC
(a) Jayne’s Story
(b) What Is Going On?
(c) Hormones and Menopause … an Introduction
(d) How Our Hormones Work… a Summary
(e) Who Suffers From Oestrogen Dominance?

CHAPTER TWO
HORMONE HEAVEN OR HORMONE HELL
(a) The Natural Female Hormone Cycle
(b) When Ovulation Fails
(c) Oestrogen and Uterine Changes
(d) Oestrogen and Breast Changes
(e) Oestrogen and Fat Deposition
(f) Reduced Energy
(g) Seeking Help
(h) Progesterone, the Anti-Oestrogen
(i) Inaccurate Serum Testing
(j) More of a Hormone Is Not Better
(k) Principal Points to Ponder

CHAPTER THREE
CHANGING TIMES IN A WOMAN’S LIFE
(a) Normal Age-Related Changes in the Female
(b) Anovulation
(c) Why take HRT?
(d) Medical Education
(e) A Critical Balance
(f) Essential Information Your Doctor Should Know
(g) Overview
(h) Progesterone… The Answer

CHAPTER FOUR
OESTROGEN AND DISEASE
(a) Symptoms of Hormone Imbalance
(b) Endometriosis
(c) Excess Oestrogen HRT
(d) What About Our Young Women?... The OC Pill
(e) Breast Cancer
(f) Obesity

CHAPTER FIVE
LAGGING LIBIDO
(a) Testosterone
(b) Testosterone Failure
(c) Evidence Of Androgen Deficiency in Women

CHAPTER SIX
OSTEOPOROSIS
(a) The Silent Thief
(b) Testosterone Grows Bones
(c) Clever Marketing… Big Pharma and Osteoporosis

CHAPTER SEVEN
BIO-IDENTICAL PROGESTERONE … The Natural Answer
(a) Natural or Synthetic?
(b) Individualised Dosing
(c) Bound and Unbound…Inactive or Active
(d) Points to Ponder

CHAPTER EIGHT
PRE-MENOPAUSE … 30-Something
(a) Pre-Menopausal Hormone Imbalance
(b) Natural Progesterone
(c) Xenoestrogens… Another Inconvenient Truth
(d) Combat Xenoestrogen Exposure

CHAPTER NINE
BIG PHARMA
(a) Medical Misinformation
(b) Medical Manipulation
(c) Corporate Profit
(d) Government Manipulation
(e) The Cancer Culprit
(f) Our Future

CHAPTER TEN
ANDROPAUSE
(a) Male Menopause
(b) A Quiz… Who Has The Most Oestrogen?
(c) Testosterone
(i) The Symptoms of Low Testosterone Function.
(ii) The Classic Symptoms of Excess Oestrogen In Men
(d) Same Hormones… Same Effects
(e) Prostate Enlargement and Prostate Cancer
(i) The Prostate Gland
(ii) Common Prostate Symptoms
(f) Medical Evidence
(i) Heart Disease
(ii) Brain Function and Memory
(iii) Prostate Disease

CHAPTER ELEVEN
STRESS AND CORTISOL
(a) Stress Kills
(b) What Happens To Us Under Stress

CHAPTER TWELVE
THE CANCER EPIDEMIC
(a) Breast and Prostate Cancer Are The Most Common
(b) Cancer Prevention

CHAPTER THIRTEEN
FAT FOOD
(a) Fast Food… Fat Food
(b) Lifestyle
(c) What is Glycaemic Index All About?
(d) How Insulin Affects Us
(e) Eating Plan Basics
(f) Exercise and Energy
(g) Exercise, Weight Loss and Metabolism
(h) Recommended Exercise
(i) Walking

CHAPTER FOURTEEN
ACTION PLAN FOR CHANGE and SUCCESS
(a) Making the Change for Better
(b) Defy the Odds and Become Exceptional
(c) Don’t Become Part of the Epidemic

SECTION TWO

APPENDIX ONE
SEX HORMONES and OTHER HORMONES
(a) The Basic Properties Of Sex Hormones
(b) The Steroidogenic Cascade
(c) Hypothalamic Control
(d) The Glycoproteins: FSH and LH
(e) POMC Hormones
(i) CRH (Corticotropin Releasing Hormone)
(ii) ACTH
(iii) Beta-endorphin
(f) Growth Hormone and Prolactin
(i) Growth Hormone
(ii) Somatomedin or IGF-1.
(iii) Prolactin
(g) Adrenal Cortical Hormones
(i) Cortisol
(ii) Aldosterone
(iii) DHEA Dehydroepiandrosterone
(iv) The Cortisol:DHEA Ratio and Health
(h) Adrenal Medullary Hormones
(i) Estradiol, Cortisol and the Hot Flush Mechanism
(j) Steroidogenesis

APPENDIX TWO
HORMONE CONTROL IN THE FEMALE
(a) Egg Production
(b) The Ovulation Process
(c) The Pulse Generator
(d) FSH and LH
(e) Female Steroidogenesis
(i) Ovarian Follicular Steroidogenesis
(ii) Ovarian Luteal Steroidogenesis
(iii) Steroidogenic Changes in Pre-menopause and
Post-menopause
(f) Aromatase
(g) Androgens
(h) Oestrogens
(i) Progesterone
(j) The Physiological Actions of Oestrogen
… and its Consequences
(k) The Physiological Actions of Progesterone
… and its Consequences
(l) The Fate of Produced 17β-estradiol (E2)

APPENDIX THREE
PREMENOPAUSE
(a) Pre-Menopause and Ovulatory Change
(b) Menopause
(c) Bio-Identical Hormones
(d) Evidence of Raised Oestrogen Levels
(i) Elevated Oestrogen in Post-Menopause
(ii) Inaccurate Serum Testing
(e) Chronic Anovulation and PCOS
(f) The Menopause Transition
(g) Oestrogen and Obesity
(h) Oestrogen and Diabetes
(i) Peri-Menopause
(j) Endometrial Hyperplasia/ Endometrial Cancer and
Oestrogen
(k) Points to Ponder

APPENDIX FOUR
ESSENTIAL KNOWLEDGE
THE MEDICAL EVIDENCE LINKING… Insulin, Blood Glucose, Oestrogen, and Breast Cancer
(a) Oestrogen Inhibits Insulin Receptors and
Causes Type 2 Diabetes
(b) Excess Insulin Upregulates Oestrogen Receptors and
Increases Cancer Risk
(c) Progesterone Decreases Cancer Risk
(d) Xenoestrogens Increase Cancer
(e) Oral Contraception and HRT Increase Cancer Risk
(f) The WHI Study
(g) Osteoporosis
(h) Androgen Deficiency in Women

APPENDIX FIVE
HORMONE CONTROL IN THE MALE
(a) Male Hormone Interactions
(b) Testosterone
(c) Aromatase in Males
(d) Dihydrotestosterone (DHT)

APPENDIX SIX
ANDROPAUSE
(a) Falling Testosterone Levels and Rising Oestrogen Levels
(b) Prostate Disease
(c) The Evidence-Based Medical Research References Confirming Oestrogen’s Role in Prostate Disease
(d) Memory, Mood and Depression
(e) Bones, Diabetes and Heart Health
(f) Testosterone Supplementation

APPENDIX SEVEN
STRESS
(a) Chronic Stress
(b) Pseudo-Cushing’s Syndrome
(c) How Stress Alters Normal Metabolism

APPENDIX EIGHT
THE CARCINOGENIC ACTIONS OF OESTROGEN
(a) Oestrogen… the Carcinogen
(i) Obesity and Cancer
(ii) Elevated Endogenous Estradiol and Cancer
(iii) Raised Androgens and Cancer
(iv) High Levels of Progesterone and Cancer Reduction
(v) Long-term Synthetic Oestrogen HRT and Cancer
(vi) Oral Contraceptive Use and Breast Cancer

(b) How Oestrogens Initiate Cancer and Promote Tumour Growth
(i) Mutation and Genotoxicity
(ii) Modulation of Immune Response

APPENDIX NINE
LEPTIN and LEPTIN RESISTANCE IN OBESITY
(a) How Leptin Resistance Contributes to Obesity, Diabetes, Oestrogen
Dominance and Cancer
(b) Leptin References in Detail

APPENDIX TEN
MELATONIN
(a) Melatonin and Light
(b) Melatonin and Age
(c) The Effects of Melatonin
(i) Melatonin and Sleep
(ii) Melatonin and Antioxidant Capacity
(iii) Melatonin and Immunity
(iv) Melatonin and “Anti-Ageing”
(v) Melatonin and Cancer
(vi) Melatonin and Ischaemia

Further Resources

For information on Menopause.
www.emenopause.com.au

For information on Andropause. www.andropause.com.au

To participate in an online consultation with Dr Graeme Williams to address your menopause or andropause problems, visit www.drgraemewilliams.com

If you would like to book Dr Williams as a speaker or to make a tax deductable donation to the
National Research Institute for the Prevention of Breast & Prostate cancer, visit our contact page